Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 6/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9148144 | 1.00 | LMNA (0.55) | LMNAHSD17B10ESR1HSD17B1SMN1; SMN2 | |
| SCHEMBL8959377 | 1.00 | LMNA (0.55) | LMNAHSD17B10ESR1HSD17B1SMN1; SMN2 | |
| SCHEMBL9144814 | 0.88 | LMNA (0.58) | LMNAHSD17B10ESR1HSD17B1SMN1; SMN2 | |
| SCHEMBL8959345 | 0.88 | LMNA (0.58) | LMNAHSD17B10ESR1HSD17B1SMN1; SMN2 | |
| SCHEMBL6861299 | 0.87 | STS (0.59) | ESR1ESR2ABCC1ABCC4STS | |
| SCHEMBL8214206 | 0.87 | STS (0.59) | ESR1ESR2ABCC1ABCC4STS | |
| SCHEMBL8959381 | 0.87 | ESR1 (0.52) | LMNAHSD17B10ESR1HSD17B1SMN1; SMN2 | |
| SCHEMBL9146993 | 0.87 | ESR1 (0.52) | LMNAHSD17B10ESR1HSD17B1SMN1; SMN2 | |
| SCHEMBL8959365 | 0.87 | ESR1 (0.52) | LMNAHSD17B10ESR1HSD17B1SMN1; SMN2 | |
| SCHEMBL259537 | 0.87 | ESR1 (0.52) | LMNAHSD17B10ESR1HSD17B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430386-B1 | 14Alpha, 17alpha bridged 16-hydroxyestratrienes | SCHERING AG (DE) | 1995-05-03 | — | — | EP | claimed |
| EP-0430386-A1 | 14Alpha, 17alpha bridged 16-hydroxyestratrienes | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-06-05 | — | — | EP | claimed |
| US-5529993-A | UROGENITAL DISORDERS; CONTRACEPTIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-06-25 | — | — | US | disclosed |
| EP-0430386-B1 | 14Alpha, 17alpha bridged 16-hydroxyestratrienes | SCHERING AG (DE) | 1995-05-03 | — | — | EP | disclosed |
| EP-0430386-A1 | 14Alpha, 17alpha bridged 16-hydroxyestratrienes | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-06-05 | — | — | EP | disclosed |