Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | ESR1 | P03372 | 3/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | SHBG | P04278 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9144814 | 1.00 | LMNA (0.58) | LMNASMN1; SMN2ESR1ADORA3ATM | |
| SCHEMBL8959387 | 0.90 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2ESR1ADORA3ATM | |
| SCHEMBL8959370 | 0.88 | LMNA (0.55) | LMNASMN1; SMN2ESR1ADORA3ATM | |
| SCHEMBL9148144 | 0.88 | LMNA (0.55) | LMNASMN1; SMN2ESR1ADORA3ATM | |
| SCHEMBL8959377 | 0.88 | LMNA (0.55) | LMNASMN1; SMN2ESR1ADORA3ATM | |
| SCHEMBL9628223 | 0.86 | LMNA (0.57) | LMNASMN1; SMN2ESR1ADORA3ATM | |
| SCHEMBL6861299 | 0.85 | STS (0.59) | ESR1ABCC1ABCC4STSKDM4E | |
| SCHEMBL8214206 | 0.85 | STS (0.59) | ESR1ABCC1ABCC4STSKDM4E | |
| SCHEMBL8959381 | 0.83 | ESR1 (0.52) | LMNASMN1; SMN2ESR1ADORA3PGR | |
| SCHEMBL9146993 | 0.83 | ESR1 (0.52) | LMNASMN1; SMN2ESR1ADORA3PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430386-B1 | 14Alpha, 17alpha bridged 16-hydroxyestratrienes | SCHERING AG (DE) | 1995-05-03 | — | — | EP | claimed |
| EP-0430386-A1 | 14Alpha, 17alpha bridged 16-hydroxyestratrienes | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-06-05 | — | — | EP | claimed |
| US-5529993-A | UROGENITAL DISORDERS; CONTRACEPTIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-06-25 | — | — | US | disclosed |
| EP-0430386-B1 | 14Alpha, 17alpha bridged 16-hydroxyestratrienes | SCHERING AG (DE) | 1995-05-03 | — | — | EP | disclosed |
| EP-0430386-A1 | 14Alpha, 17alpha bridged 16-hydroxyestratrienes | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-06-05 | — | — | EP | disclosed |