Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | ICMT | O60725 | 6/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959509 | 1.00 | HTR2A (0.51) | HTR2AHTR2CKMOHTR6ICMT | |
| SCHEMBL8959699 | 0.87 | HTR2A (0.63) | HTR2AHTR2CKMOHTR6ICMT | |
| Fumaric Acid SCHEMBL27352021 | 0.83 | HTR2C (0.79) | HTR2AHTR2CICMT | |
| Fumaric Acid SCHEMBL8959757 | 0.83 | HTR2C (0.79) | HTR2AHTR2CICMT | |
| Fumaric Acid SCHEMBL8959552 | 0.83 | HTR2C (0.79) | HTR2AHTR2CICMT | |
| Fumaric Acid SCHEMBL8959841 | 0.83 | HTR2C (0.79) | HTR2AHTR2CICMT | |
| Fumaric Acid SCHEMBL8959746 | 0.83 | HTR2C (0.79) | HTR2AHTR2CICMT | |
| Fumaric Acid SCHEMBL8959489 | 0.77 | KMO (0.53) | HTR2AHTR2CKMOKRASMCL1 | |
| Fumaric Acid SCHEMBL8959483 | 0.77 | KMO (0.53) | HTR2AHTR2CKMOKRASMCL1 | |
| Fumaric Acid SCHEMBL8959620 | 0.76 | HDAC6 (0.54) | HTR2AHTR2CKMOKRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |