Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7778483 | 0.84 | ALDH1A1 (0.55) | MCL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL9573821 | 0.83 | TUBB4A (0.51) | MCL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL3255506 | 0.83 | GPR17 (0.55) | MCL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL8959749 | 0.82 | KDM4E (0.51) | ALDH1A1KDM4EMAPTKMT2APOLB | |
| SCHEMBL29113502 | 0.80 | PTGER1 (0.45) | MCL1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL15516976 | 0.80 | MCL1 (0.44) | MCL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL9233403 | 0.79 | TUBB4A (0.37) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL11547200 | 0.78 | MCL1 (0.43) | MCL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL27514059 | 0.77 | GPR17 (0.39) | MCL1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3830749 | 0.76 | MAPT (0.46) | MCL1ALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |