Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 4/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.38 |
| ▸ | TUBB | P07437 | 2/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31332322 | 0.77 | GPR84 (0.46) | HTR1AHTR2AGPR84HTR6HTR7 | |
| SCHEMBL28167759 | 0.75 | FFAR1 (0.53) | HTR1AHTR2AGPR84HTR6HTR7 | |
| SCHEMBL27413732 | 0.72 | GPR84 (0.50) | HTR1AHTR2AGPR84HTR6HTR7 | |
| SCHEMBL28337297 | 0.71 | NR4A2 (0.55) | HTR1AHTR2AGPR84HTR6HTR7 | |
| SCHEMBL29953802 | 0.69 | CYP2A6 (0.47) | HTR1AGPR84 | |
| SCHEMBL12804213 | 0.69 | HTR2A (0.47) | HTR2ATUBB1HTR2CHTR2B | |
| SCHEMBL28167758 | 0.68 | HTR2A (0.60) | HTR1AHTR2AHTR6HTR7HTR2C | |
| SCHEMBL24189182 | 0.68 | HTR2A (0.59) | HTR1AHTR2AGPR84HTR6HTR7 | |
| SCHEMBL28167760 | 0.68 | IDO1 (0.60) | HTR2AGPR84IDO1TUBB4ATUBB | |
| SCHEMBL5746977 | 0.68 | NR4A2 (0.35) | HTR1AHTR2AGPR84HTR6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |