Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.58 |
| ▸ | HTR2A | P28223 | 10/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959486 | 0.85 | HTR2C (0.58) | HTR2CHTR2APRMT5HDAC3HDAC1 | |
| SCHEMBL8959627 | 0.82 | HTR2C (0.60) | HTR2CHTR2AHDAC1HDAC8HDAC6 | |
| SCHEMBL23927907 | 0.82 | HTR2C (0.51) | HTR2CHTR2APRMT5HDAC3HDAC1 | |
| Fumaric Acid SCHEMBL8959568 | 0.78 | HTR2C (0.59) | HTR2CHTR2APRMT5PPARGCYP1A2 | |
| Fumaric Acid SCHEMBL8959578 | 0.78 | HTR2C (0.59) | HTR2CHTR2APRMT5PPARGCYP1A2 | |
| SCHEMBL11032483 | 0.78 | HTR2C (0.65) | HTR2CHTR2APRMT5HDAC3HDAC1 | |
| Fumaric Acid SCHEMBL8959669 | 0.78 | HTR2C (0.78) | HTR2CHTR2APRMT5CYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL8959795 | 0.78 | HTR2C (0.78) | HTR2CHTR2APRMT5CYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL8959482 | 0.78 | HTR2C (0.78) | HTR2CHTR2APRMT5CYP1A2CYP3A4 | |
| Fumaric Acid SCHEMBL8959800 | 0.78 | HTR2C (0.78) | HTR2CHTR2APRMT5CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |