Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.58 |
| ▸ | HTR2A | P28223 | 7/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 2/20 | 0.40 |
| ▸ | ACLY | P53396 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673292 | 0.90 | KMO (0.50) | HTR2CHTR2APRMT5ACLYOXER1 | |
| SCHEMBL8959694 | 0.85 | HTR2C (0.58) | HTR2CHTR2APRMT5HDAC3HDAC1 | |
| SCHEMBL8959627 | 0.82 | HTR2C (0.60) | HTR2CHTR2AKRASHDAC1HDAC8 | |
| SCHEMBL8959507 | 0.78 | HTR2C (0.60) | HTR2CHTR2AKRASCYP1A2CYP3A4 | |
| SCHEMBL4042963 | 0.78 | HTR2C (0.65) | HTR2CHTR2APRMT5ACLYHDAC3 | |
| SCHEMBL4042962 | 0.78 | HTR2C (0.65) | HTR2CHTR2APRMT5ACLYHDAC3 | |
| Fumaric Acid SCHEMBL7091385 | 0.78 | HTR2C (0.78) | HTR2CHTR2APRMT5KRASACLY | |
| Fumaric Acid SCHEMBL7091387 | 0.78 | HTR2C (0.78) | HTR2CHTR2APRMT5KRASACLY | |
| SCHEMBL7677260 | 0.78 | HTR2C (0.45) | HTR2CHTR2APRMT5HDAC3HDAC1 | |
| SCHEMBL3951044 | 0.76 | HTR2C (0.63) | HTR2CHTR2APRMT5KRASACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |