Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 3/20 | 0.57 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822934 | 0.83 | EIF4A3 (0.68) | EIF4A3GPR35KDM4EHSD17B10HPGD | |
| SCHEMBL22747185 | 0.83 | GPR35 (0.51) | EIF4A3GPR35KDM4EHSD17B10HPGD | |
| SCHEMBL8959784 | 0.79 | ALDH1A1 (0.58) | EIF4A3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL10003114 | 0.79 | FGFR1 (0.39) | EIF4A3GPR35KDM4EHSD17B10HPGD | |
| SCHEMBL9232962 | 0.77 | EGLN1 (0.39) | EIF4A3EGLN1FGFR1FGFR2FGFR3 | |
| SCHEMBL3639230 | 0.77 | EIF4A3 (0.60) | EIF4A3GPR35KDM4EHSD17B10HPGD | |
| SCHEMBL17429451 | 0.77 | EIF4A3 (0.65) | EIF4A3GPR35KDM4EHSD17B10HPGD | |
| SCHEMBL30147531 | 0.75 | EIF4A3 (0.77) | EIF4A3GPR35KDM4EHSD17B10HPGD | |
| SCHEMBL29301295 | 0.75 | EIF4A3 (0.77) | EIF4A3GPR35KDM4EHSD17B10HPGD | |
| SCHEMBL16915508 | 0.75 | GPR35 (0.43) | EIF4A3GPR35KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |