Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 8/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959949 | 0.88 | SLC22A12 (0.35) | ICMTKMT2A | |
| SCHEMBL8959909 | 0.79 | ICMT (0.32) | ICMT | |
| SCHEMBL8959713 | 0.78 | HTR2A (0.49) | — | |
| SCHEMBL8959561 | 0.78 | HTR2A (0.49) | — | |
| SCHEMBL27363223 | 0.78 | HTR2A (0.49) | — | |
| SCHEMBL8959864 | 0.76 | HTR2A (0.49) | — | |
| Fumaric Acid SCHEMBL8959840 | 0.72 | HTR2A (0.46) | ICMT | |
| Fumaric Acid SCHEMBL8959846 | 0.72 | HTR2A (0.46) | ICMT | |
| Fumaric Acid SCHEMBL27359202 | 0.72 | HTR2A (0.46) | ICMT | |
| SCHEMBL8959753 | 0.70 | HTR2A (0.48) | ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |