Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | MAOB | P27338 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959997 | 1.00 | NPC1 (0.73) | NPC1RAB9ATDP1MAOBSMN1; SMN2 | |
| SCHEMBL31745436 | 0.91 | MAOB (0.62) | NPC1RAB9ATDP1MAOBSMN1; SMN2 | |
| SCHEMBL657690 | 0.85 | NPC1 (1.00) | NPC1RAB9ATDP1MAOBSMN1; SMN2 | |
| SCHEMBL29522745 | 0.85 | NPC1 (1.00) | NPC1RAB9ATDP1MAOBSMN1; SMN2 | |
| SCHEMBL657691 | 0.85 | NPC1 (1.00) | NPC1RAB9ATDP1MAOBSMN1; SMN2 | |
| SCHEMBL8959963 | 0.79 | NPC1 (0.68) | NPC1RAB9ATDP1MAOBSMN1; SMN2 | |
| SCHEMBL8959956 | 0.79 | NPC1 (0.68) | NPC1RAB9ATDP1MAOBSMN1; SMN2 | |
| SCHEMBL14692452 | 0.77 | MAPT (0.72) | NPC1RAB9AMAOBSMN1; SMN2MAPT | |
| SCHEMBL30384796 | 0.77 | MAPT (0.72) | NPC1RAB9AMAOBSMN1; SMN2MAPT | |
| SCHEMBL14692453 | 0.77 | MAPT (0.72) | NPC1RAB9AMAOBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530019-A | FOR TREATMENT OF PROSTATE GLAND DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0648208-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| WO-1994022821-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |