SCHEMBL14692452

SCHEMBL14692452

COc1ccc(/C=C/C(=O)c2ccccc2I)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.72
MAOB P27338 4/20 0.72
CYP2C19 P33261 2/20 0.72
CYP2D6 P10635 2/20 0.72
CYP2C9 P11712 1/20 0.72
MAOA P21397 1/20 0.72
CASP3 P42574 1/20 0.72
SENP8 Q96LD8 1/20 0.72
SENP7 Q9BQF6 1/20 0.72
SENP6 Q9GZR1 1/20 0.72
CYP3A4 P08684 2/20 0.64
BCHE P06276 1/20 0.64
NFKB1 P19838 1/20 0.64
NFKB2 Q00653 1/20 0.64
RELA Q04206 1/20 0.64
ACHE P22303 2/20 0.62
BACE1 P56817 2/20 0.62
ABCG2 Q9UNQ0 6/20 0.61
TUBB4A P04350 2/20 0.61
TUBB P07437 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14692453 1.00 MAPT (0.72) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL30384796 1.00 MAPT (0.72) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL14692306 0.85 MAOB (0.74) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL14692307 0.85 MAOB (0.74) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL25196440 0.84 MAPT (0.74) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL30807155 0.84 MAPT (1.00) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL2807601 0.84 MAPT (1.00) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL2807599 0.84 MAPT (1.00) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL25192231 0.83 APP (0.74) MAPTMAOBCYP2C19CYP2D6CYP2C9
SCHEMBL14692614 0.82 MAPT (0.66) MAPTMAOBCYP2C19CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
US-20160214918-A1 COMPOSITION FOR TREATING METABOLIC SYNDROME AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2016-07-28 US disclosed
US-9085520-B2 Composition for treating diabetes and metabolic diseases and a preparation method thereof KAOHSIUNG MEDICAL UNIVERSITY (TW) 2015-07-21 US disclosed
US-9085520-B2 Composition for treating diabetes and metabolic diseases and a preparation method thereof KAOHSIUNG MEDICAL UNIVERSITY (TW) 2015-07-21 US disclosed
US-9085520-B2 Composition for treating diabetes and metabolic diseases and a preparation method thereof KAOHSIUNG MEDICAL UNIVERSITY (TW) 2015-07-21 US disclosed
US-20140350304-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-11-27 US disclosed
US-20140350304-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-11-27 US disclosed
US-20140350304-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-11-27 US disclosed
US-20140194474-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-07-10 US disclosed
US-20140194474-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2014-07-10 US disclosed
US-20130040996-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-14 US disclosed
US-20130040996-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-14 US disclosed
WO-2013022951-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-14 WO disclosed
WO-2013022951-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-02-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130040996-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF CDK4, PPARD, CCND1 MAPT 4298/4885MAOB 3661/4885CYP2C19 1615/4885
US-20140194474-A1 COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF CDK4, PPARD, CCND1 MAPT 4298/4885MAOB 3661/4885CYP2C19 1615/4885
US-20160214918-A1 COMPOSITION FOR TREATING METABOLIC SYNDROME AND A PREPARATION METHOD THEREOF C1S, CYP2S1, ACSS2 MAPT 4468/4885MAOB 1283/4885CYP2C19 248/4885
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAPT 3297/4885MAOB 1004/4885CYP2C19 109/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885MAOB 2435/4885CYP2C19 583/4885
US-20140350304-A1 COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF FABP1, GYS2, CYP7B1 MAPT 4070/4885MAOB 3332/4885CYP2C19 193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.