Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | MAOB | P27338 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959956 | 1.00 | NPC1 (0.68) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL657691 | 0.82 | NPC1 (1.00) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL29522745 | 0.82 | NPC1 (1.00) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL657690 | 0.82 | NPC1 (1.00) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL8960003 | 0.79 | NPC1 (0.73) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL8959997 | 0.79 | NPC1 (0.73) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL9159676 | 0.76 | MAPT (0.48) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL8959862 | 0.74 | MAPT (0.51) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL8959856 | 0.74 | MAPT (0.51) | NPC1RAB9ATDP1MAOBMAPT | |
| SCHEMBL8959873 | 0.74 | MAPT (0.61) | MAPTHPGDHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530019-A | FOR TREATMENT OF PROSTATE GLAND DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0648208-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| WO-1994022821-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |