Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10752371 | 0.98 | HRH3 (0.43) | HRH3KCNH2CHRNB4CHRNA3CYP2D6 | |
| SCHEMBL19998539 | 0.86 | HRH3 (0.55) | HRH3KCNH2CYP2D6HSD11B1KDM4E | |
| SCHEMBL11434566 | 0.78 | HTR2C (0.44) | — | |
| Hydrochloric Acid SCHEMBL11436080 | 0.77 | HTR2C (0.45) | — | |
| SCHEMBL10644523 | 0.76 | CHRNB4 (0.60) | CHRNB4CHRNA3LSS | |
| SCHEMBL19459080 | 0.74 | CHRNB2 (0.47) | HRH3KCNH2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL10760183 | 0.74 | CHRNB4 (0.58) | CHRNB4CHRNA3LSS | |
| SCHEMBL917376 | 0.74 | HSD11B1 (0.43) | HRH3KCNH2CHRNB4CHRNA3HSD11B1 | |
| SCHEMBL6099117 | 0.73 | HSD11B1 (0.40) | CYP2D6HSD11B1KDM4ETSHR | |
| SCHEMBL10057644 | 0.73 | KCNH2 (0.60) | HRH3KCNH2CYP2D6KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0192521-B1 | 3-PHENYL-TETRAHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-12-14 | — | — | EP | claimed |
| US-4663328-A | 3-Phenyl-tetrahydropyridine derivatives, and their use as sedative agents | LABORATOIRE L. LAFON (FR) | 1987-05-05 | — | — | US | claimed |
| EP-0192521-A1 | 3-Phenyl-tetrahydropyridine derivatives, process for their preparation and their therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | claimed |
| EP-0691956-A1 | 3-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES AS SEDATIVES | LABORATOIRE L. LAFON (FR) | 1996-01-17 | — | — | EP | disclosed |
| US-5439920-A | Sedatives, anxiolytic agents | LABORATOIRE L. LAFON (FR) | 1995-08-08 | — | — | US | disclosed |
| WO-1994022827-A1 | 3-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES AS SEDATIVES | LABORATOIRE L. LAFON (FR) | 1994-10-13 | — | — | WO | disclosed |
| EP-0618194-A1 | 3-Phenyl-1,2,5,6-tetrahydropyridine and its use as a sedative | LABORATOIRE L. LAFON (FR) | 1994-10-05 | — | — | EP | disclosed |
| EP-0192521-B1 | 3-PHENYL-TETRAHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1988-12-14 | — | — | EP | disclosed |
| US-4663328-A | 3-Phenyl-tetrahydropyridine derivatives, and their use as sedative agents | LABORATOIRE L. LAFON (FR) | 1987-05-05 | — | — | US | disclosed |
| EP-0192521-A1 | 3-Phenyl-tetrahydropyridine derivatives, process for their preparation and their therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-08-27 | — | — | EP | disclosed |