Naphthalene

Naphthalene

SCHEMBL8960977

COC(OC(C)=O)OC(C)=O.c1ccc2ccccc2c1

nearest known ligand 0.42

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
CYP3A4 P08684 1/20 0.42
TSHR P16473 2/20 0.36
KMT2A Q03164 1/20 0.35
KDM4E B2RXH2 2/20 0.35
HPGD P15428 1/20 0.35
CYP2A6 P11509 2/20 0.34
CYP1A2 P05177 1/20 0.34
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
MMP12 P39900 1/20 0.34
ALOX12 P18054 1/20 0.33
PABPC1 P11940 1/20 0.33
APOBEC3A P31941 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
GLA P06280 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthalene SCHEMBL8961256 0.79 ALDH1A1 (0.39) ALDH1A1CYP3A4TSHRHPGDL3MBTL1
Naphthalene SCHEMBL29253171 0.78 TSHR (0.64) ALDH1A1CYP3A4TSHRKMT2AKDM4E
Naphthalene SCHEMBL1961577 0.77 ALDH1A1 (0.56) ALDH1A1TSHRKMT2AKDM4EHPGD
SCHEMBL784062 0.77
Naphthalene SCHEMBL29016507 0.72 ALDH1A1 (0.56) ALDH1A1TSHRKMT2AKDM4EHPGD
Naphthalene SCHEMBL27879233 0.72 CYP2A6 (0.44) ALDH1A1TSHRKMT2AKDM4EHPGD
Naphthalene SCHEMBL2217332 0.71 CYP2A6 (0.57) ALDH1A1TSHRKMT2AKDM4EHPGD
SCHEMBL783559 0.71 MTNR1A (0.47) ALDH1A1CYP3A4KMT2AHPGDCYP1A2
SCHEMBL4186797 0.69 UGT2B7 (0.52) ALDH1A1CYP3A4TSHRKMT2ACYP1A2
SCHEMBL1030015 0.69 ALDH1A1 (0.53) ALDH1A1CYP3A4TSHRKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0693877-A1 USE OF 7-ETHYNYL $g(a)-(METHOXYMETHYLENE) 1-NAPHTHALENE ACETIC ACID DERIVATIVES FOR PREPARING FUNGICIDAL COMPOSITIONS ROUSSEL UCLAF (FR) 1996-01-31 EP disclosed
WO-1994023576-A1 USE OF 7-ETHYNYL α-(METHOXYMETHYLENE) 1-NAPHTHALENE ACETIC ACID DERIVATIVES FOR PREPARING FUNGICIDAL COMPOSITIONS ROUSSEL UCLAF (FR) 1994-10-27 WO disclosed