SCHEMBL8961709

SCHEMBL8961709

CC[Si](CC)(CC)CC(=O)OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.46
HSD17B10 Q99714 3/20 0.42
MGAM O43451 2/20 0.42
GAA P10253 2/20 0.42
SI P14410 2/20 0.42
MGAM2 Q2M2H8 2/20 0.42
TET2 Q6N021 1/20 0.39
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 2/20 0.33
CA12 O43570 2/20 0.33
CA14 Q9ULX7 2/20 0.33
KDM4E B2RXH2 1/20 0.33
RECQL P46063 1/20 0.33
ALDH1A1 P00352 4/20 0.32
HTT P42858 2/20 0.32
MAPT P10636 1/20 0.32
POLB P06746 1/20 0.31
POLA1 P09884 1/20 0.31
HSP90AB1 P08238 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL990791 0.72
SCHEMBL27988733 0.70 TSHR (0.48) TSHRHSD17B10MGAMGAASI
SCHEMBL4347462 0.70 TSHR (0.48) TSHRHSD17B10MGAMGAASI
SCHEMBL3912265 0.70 TSHR (0.42) TSHRHSD17B10MGAMGAASI
SCHEMBL9486619 0.69 ALDH1A1 (0.44) HSD17B10LMNAALDH1A1
SCHEMBL5711158 0.69 FFAR3 (0.44) TSHRHSD17B10KMT2AMEN1LMNA
SCHEMBL3917953 0.69 TSHR (0.40) TSHRHSD17B10MGAMGAASI
SCHEMBL13151016 0.68
SCHEMBL3919522 0.68 TSHR (0.46) TSHRHSD17B10MGAMGAASI
SCHEMBL3288569 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0424000-B1 Novel silicone polymers, copolymers and block copolymers and a method for their preparation DOW CORNING (US) 1996-02-07 EP disclosed
US-5371147-A Silicone-containing acrylic star polymers, block copolymers and macromonomers PERMEABLE TECHNOLOGIES, INC. (US) 1994-12-06 US disclosed
US-5331067-A Acrylic polymers containing trimethylsiloxy groups PERMEABLE TECHNOLOGIES, INC. (US) 1994-07-19 US disclosed
US-5314961-A Acrylic-silicone polymers PERMEABLE TECHNOLOGIES, INC. (US) 1994-05-24 US disclosed
US-5314960-A Silicone-containing polymers, oxygen permeable hydrophilic contact lenses and methods for making these lenses and treating patients with visual impairment PERMEABLE TECHNOLOGIES, INC. (US) 1994-05-24 US disclosed
US-5244981-A Acrylic polymers with pendant silicon containing groups, macromonomers, star polymers PERMEABLE TECHNOLOGIES, INC. (US) 1993-09-14 US disclosed
EP-0552306-A1 NOVEL SILICONE-CONTAINING POLYMERS AND OXYGEN PERMEABLE HYDROPHILIC CONTACT LENSES THEREFROM PERMEABLE TECHNOLOGIES, INC. (US) 1993-07-28 EP disclosed
US-5212229-A MONODISPERSED ACRYLIC POLYMERS IN SUPERCRITICAL, NEAR SUPERCRITICAL AND SUBCRITICAL FLUIDS UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1993-05-18 US disclosed
EP-0407414-B1 CATALYST FOR GROUP TRANSFER POLYMERIZATION E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-01-27 EP disclosed
US-5171809-A Silicone-acrylate copolymer DOW CORNING CORPORATION (US) 1992-12-15 US disclosed
US-4711942-A FROM ACRYLIC OR MALEIMIDE MONOMER AND ORGANOSILICON,-TIN, OR -GERMANIUM INITIATOR E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-12-08 US disclosed
US-4681918-A ACRYLIC-TYPE OR MALEIMIDE MONOMERS; ORGANOSILICON, TIN OR GERMANIUM INITIATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-21 US disclosed
EP-0068887-B1 \"LIVING\" POLYMERS AND PROCESS FOR THEIR PREPARATION E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-09-24 EP disclosed
US-4581428-A Process for preparing \"living\" polymers using tetracoordinate organosilicon, organotin or organogermanium polymerization initiator with bifluoride ion source co-catalyst E. I. DU PONT DE NEMOURS AND COMPANY (US) 1986-04-08 US disclosed
EP-0145263-A1 Living polymers and process for their preparation E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-06-19 EP disclosed
US-4524196-A Process for preparing \"living\" polymers E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-06-18 US disclosed
US-4508880-A ACRYLIC OR MALEIMIDE MONOMERS WITH ORGANOSILICON, (-TIN, OR-GERMANIUM) INITIATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-02 US disclosed
US-4417034-A POLYMERIZING ACRYLIC OR MALEIMIDE MONOMERS WITH ORGANO-SILICON, -TIN, OR-GERMANIUM INITIATORS E. I. DU PONT DE NEMOURS & CO. (US) 1983-11-22 US disclosed
US-4414372-A ADDITION POLYMERS WITH FUNCTIONAL END GROUPS E. I. DU PONT DE NEMOURS & CO. (US) 1983-11-08 US disclosed
EP-0068887-A1 \"Living\" polymers and process for their preparation E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-01-05 EP disclosed