Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 9/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EEF2K | O00418 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962003 | 1.00 | PTGS1 (0.56) | PTGS1PTGS2GAAMEN1ALDH1A1 | |
| SCHEMBL8962112 | 1.00 | PTGS1 (0.56) | PTGS1PTGS2GAAMEN1ALDH1A1 | |
| SCHEMBL7745576 | 0.74 | GAA (0.50) | PTGS1PTGS2GAAMEN1ALDH1A1 | |
| SCHEMBL8962055 | 0.73 | GAA (0.49) | PTGS1PTGS2GAAMEN1ALDH1A1 | |
| SCHEMBL7701813 | 0.72 | PTGS2 (1.00) | PTGS1PTGS2GAAALDH1A1EEF2K | |
| SCHEMBL7701809 | 0.72 | PTGS2 (1.00) | PTGS1PTGS2GAAALDH1A1EEF2K | |
| SCHEMBL7701811 | 0.72 | PTGS2 (1.00) | PTGS1PTGS2GAAALDH1A1EEF2K | |
| SCHEMBL7702588 | 0.72 | GAA (1.00) | PTGS1PTGS2GAAMEN1ALDH1A1 | |
| SCHEMBL7702586 | 0.72 | GAA (1.00) | PTGS1PTGS2GAAMEN1ALDH1A1 | |
| SCHEMBL15321396 | 0.71 | SMN1; SMN2 (0.50) | PTGS2GAAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494927-A | INHIBITS ACTIVITY OF 5-LIPOXYGENASE AND-OR CYCLOOXYGENASE | WARNER-LAMBERT COMPANY (US) | 1996-02-27 | — | — | US | claimed |
| EP-0449216-B1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER LAMBERT CO (US) | 1996-02-07 | — | — | EP | claimed |
| EP-0449216-A1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | claimed |
| US-5494927-A | INHIBITS ACTIVITY OF 5-LIPOXYGENASE AND-OR CYCLOOXYGENASE | WARNER-LAMBERT COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0449216-B1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER LAMBERT CO (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5290800-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1994-03-01 | — | — | US | disclosed |
| US-5143928-A | Inhibitors of cyclooxygenase and lipoxygenase | WARNER-LAMBERT COMPANY (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0449216-A1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |