Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MITF | O75030 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962128 | 1.00 | PTGS2 (0.70) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL8962123 | 1.00 | PTGS2 (0.70) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL7701809 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1ALOX5MAPTALDH1A1 | |
| SCHEMBL7701811 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1ALOX5MAPTALDH1A1 | |
| SCHEMBL7701813 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1ALOX5MAPTALDH1A1 | |
| SCHEMBL8962034 | 0.80 | PTGS2 (0.75) | PTGS2PTGS1ALOX5CYP1A2CYP2C9 | |
| SCHEMBL8962043 | 0.80 | PTGS2 (0.75) | PTGS2PTGS1ALOX5CYP1A2CYP2C9 | |
| SCHEMBL8962039 | 0.80 | PTGS2 (0.75) | PTGS2PTGS1ALOX5CYP1A2CYP2C9 | |
| SCHEMBL8962192 | 0.77 | PTGS2 (0.78) | PTGS2PTGS1ALOX5CYP1A2CYP2C9 | |
| SCHEMBL8962137 | 0.77 | PTGS2 (0.78) | PTGS2PTGS1ALOX5CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449216-B1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER LAMBERT CO (US) | 1996-02-07 | — | — | EP | claimed |
| US-5143928-A | Inhibitors of cyclooxygenase and lipoxygenase | WARNER-LAMBERT COMPANY (US) | 1992-09-01 | — | — | US | claimed |
| EP-0449216-A1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | claimed |