⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962467 | 0.91 | MAPK1 (0.43) | — | |
| SCHEMBL8962537 | 0.81 | LMNA (0.46) | — | |
| SCHEMBL8962780 | 0.78 | — | — | |
| SCHEMBL7104643 | 0.75 | — | — | |
| SCHEMBL8962427 | 0.70 | — | — | |
| SCHEMBL19236698 | 0.70 | SCN5A (0.49) | — | |
| SCHEMBL1952758 | 0.69 | SCN5A (0.58) | — | |
| Hydrochloric Acid SCHEMBL19209655 | 0.68 | SCN5A (0.51) | — | |
| Hydrochloric Acid SCHEMBL19209656 | 0.68 | SCN5A (0.51) | — | |
| SCHEMBL8962531 | 0.68 | SMN1; SMN2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491170-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-02-13 | — | — | US | claimed |
| WO-1996019446-A1 | β-CARBOXY SULFONAMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | disclosed |
| US-5491170-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-02-13 | — | — | US | disclosed |