Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962842 | 1.00 | JAK2 (0.35) | JAK2HDAC2CYP11B1CYP11B2DGAT1 | |
| SCHEMBL8963228 | 0.89 | P2RY14 (0.35) | HDAC2CYP11B1CYP11B2DGAT1NPC1 | |
| SCHEMBL8963237 | 0.89 | P2RY14 (0.35) | HDAC2CYP11B1CYP11B2DGAT1NPC1 | |
| SCHEMBL8962613 | 0.88 | SLC6A2 (0.35) | HDAC2KCNH2 | |
| SCHEMBL8962617 | 0.88 | SLC6A2 (0.35) | HDAC2KCNH2 | |
| SCHEMBL8380316 | 0.88 | FFAR1 (0.33) | JAK2HDAC2CYP11B1CYP11B2DGAT1 | |
| SCHEMBL9313856 | 0.88 | FFAR1 (0.33) | JAK2HDAC2CYP11B1CYP11B2DGAT1 | |
| SCHEMBL9313850 | 0.88 | FFAR1 (0.33) | JAK2HDAC2CYP11B1CYP11B2DGAT1 | |
| SCHEMBL8380314 | 0.88 | FFAR1 (0.33) | JAK2HDAC2CYP11B1CYP11B2DGAT1 | |
| SCHEMBL8962932 | 0.85 | KDM1A (0.37) | HDAC2NPC1RAB9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0559860-A1 | HALOVINYL-DERIVATIVES. | HOFFMANN LA ROCHE (CH) | 1993-09-15 | — | — | EP | disclosed |
| WO-1993007234-A1 | HALOVINYL-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-15 | — | — | WO | disclosed |