Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.55 |
| ▸ | HTR3B | O95264 | 2/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9657638 | 0.94 | HTR3E (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Fumaric Acid SCHEMBL9657647 | 0.94 | HTR3E (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9656084 | 0.85 | HTR3A (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL9657354 | 0.83 | HTR3A (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Fumaric Acid SCHEMBL9657361 | 0.83 | HTR3A (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9657640 | 0.82 | HTR3A (0.48) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8962689 | 0.81 | HTR3E (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Succinic Acid SCHEMBL9656150 | 0.78 | HTR3E (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9657326 | 0.76 | HTR3E (0.55) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7316844 | 0.75 | HTR3A (0.65) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530008-A | USEFUL FOR TREATING ANXIETY DISORDER AND AGORAPHOBIA | SANDOZ LTD. (CH) | 1996-06-25 | — | — | US | claimed |
| EP-0422154-B1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS | SANDOZ AG (AT) | 1993-12-01 | — | — | EP | claimed |
| EP-0291172-B1 | KETONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | claimed |
| US-5019586-A | 5-Hydroxytryptamine Receptor Antagonists | GLAXO GROUP LIMITED | 1991-05-28 | — | — | US | claimed |
| EP-0422154-A1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS. | SANDOZ AG (AT) | 1991-04-17 | — | — | EP | claimed |
| WO-1990012569-A1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS | SANDOZ AG (CH) | 1990-11-01 | — | — | WO | claimed |
| EP-0291172-A1 | Ketone derivatives | GLAXO GROUP LIMITED (GB) | 1988-11-17 | — | — | EP | claimed |
| US-5530008-A | USEFUL FOR TREATING ANXIETY DISORDER AND AGORAPHOBIA | SANDOZ LTD. (CH) | 1996-06-25 | — | — | US | disclosed |
| EP-0422154-B1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS | SANDOZ AG (AT) | 1993-12-01 | — | — | EP | disclosed |
| EP-0291172-B1 | KETONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| US-5084474-A | Antagonist of 5-hydroxytryptamine receptors on nerves and useful for treatment of psychotic disorders, anxiety, and nausea and vomiting, compounds of imidazole | GLAXO GROUP LIMITED (GB) | 1992-01-28 | — | — | US | disclosed |
| US-5019586-A | 5-Hydroxytryptamine Receptor Antagonists | GLAXO GROUP LIMITED | 1991-05-28 | — | — | US | disclosed |
| EP-0422154-A1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS. | SANDOZ AG (AT) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990012569-A1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS | SANDOZ AG (CH) | 1990-11-01 | — | — | WO | disclosed |
| US-4918080-A | ANXIOLYTIC AGENTS, ANTIEMETICS | GLAXO GROUP LIMITED (GB) | 1990-04-17 | — | — | US | disclosed |
| EP-0291172-A1 | Ketone derivatives | GLAXO GROUP LIMITED (GB) | 1988-11-17 | — | — | EP | disclosed |