Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962982 | 1.00 | KDM1A (0.44) | KDM1ANAAAJAK2NR1H4PRMT5 | |
| SCHEMBL8962940 | 0.91 | HRH3 (0.36) | KDM1AJAK2NR1H4PRMT5FPR2 | |
| SCHEMBL8962946 | 0.91 | HRH3 (0.36) | KDM1AJAK2NR1H4PRMT5FPR2 | |
| SCHEMBL20803726 | 0.91 | KDM1A (0.46) | KDM1ANAAANR1H4PTGS2FAAH | |
| SCHEMBL20803723 | 0.89 | KDM1A (0.45) | KDM1ANAAANR1H4PTGS2FAAH | |
| SCHEMBL8962824 | 0.87 | KDM1A (0.41) | KDM1ANAAAFAAH | |
| SCHEMBL8962831 | 0.87 | KDM1A (0.41) | KDM1ANAAAFAAH | |
| SCHEMBL20803595 | 0.86 | KDM1A (0.46) | KDM1ANAAANR1H4PTGS2FAAH | |
| SCHEMBL20803586 | 0.86 | KDM1A (0.46) | KDM1ANAAANR1H4PTGS2FAAH | |
| SCHEMBL22161983 | 0.86 | KDM1A (0.46) | KDM1ANAAANR1H4PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |
| WO-1993007234-A1 | HALOVINYL-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-15 | — | — | WO | disclosed |