Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 8/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962946 | 1.00 | HRH3 (0.36) | HRH3KDM1AFPR2PDE4BNR1H4 | |
| SCHEMBL8962990 | 0.91 | KDM1A (0.44) | HRH3KDM1AFPR2NR1H4PRMT5 | |
| SCHEMBL8962982 | 0.91 | KDM1A (0.44) | HRH3KDM1AFPR2NR1H4PRMT5 | |
| SCHEMBL9540986 | 0.91 | NAAA (0.38) | HRH3KDM1AFPR2NR1H4PRMT5 | |
| SCHEMBL20803584 | 0.86 | GABRA1 (0.39) | HRH3KDM1AFPR2PDE4BPDE4A | |
| SCHEMBL8962824 | 0.85 | KDM1A (0.41) | KDM1A | |
| SCHEMBL8962831 | 0.85 | KDM1A (0.41) | KDM1A | |
| SCHEMBL8962630 | 0.82 | RAB9A (0.41) | HRH3 | |
| SCHEMBL8962634 | 0.82 | RAB9A (0.41) | HRH3 | |
| SCHEMBL20803726 | 0.81 | KDM1A (0.46) | HRH3KDM1AFPR2NR1H4PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |