Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 8/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962824 | 1.00 | KDM1A (0.41) | KDM1ACYP17A1PDGFRBPDGFRATDP2 | |
| SCHEMBL8962990 | 0.87 | KDM1A (0.44) | KDM1ANAAAFAAH | |
| SCHEMBL8962982 | 0.87 | KDM1A (0.44) | KDM1ANAAAFAAH | |
| SCHEMBL8963104 | 0.85 | JAK2 (0.34) | — | |
| SCHEMBL8963112 | 0.85 | JAK2 (0.34) | — | |
| SCHEMBL8963179 | 0.85 | CTSK (0.37) | NAAAGRIN2BFAAH | |
| SCHEMBL8963176 | 0.85 | CTSK (0.37) | NAAAGRIN2BFAAH | |
| SCHEMBL8962940 | 0.85 | HRH3 (0.36) | KDM1A | |
| SCHEMBL8962946 | 0.85 | HRH3 (0.36) | KDM1A | |
| SCHEMBL20803588 | 0.85 | KDM1A (0.43) | KDM1ACYP17A1PDGFRBPDGFRATDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |