Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963681 | 0.95 | CYP3A4 (0.53) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| Lifarizine SCHEMBL676318 | 0.85 | DRD2 (0.57) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| Lifarizine SCHEMBL8963776 | 0.84 | DRD2 (0.56) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| SCHEMBL8963806 | 0.84 | CYP3A4 (0.56) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| Lifarizine SCHEMBL14809613 | 0.83 | CYP3A4 (0.57) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| Lifarizine SCHEMBL94691 | 0.83 | CYP3A4 (0.57) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| Lifarizine SCHEMBL2231142 | 0.82 | CYP3A4 (0.56) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| SCHEMBL8963815 | 0.82 | CYP3A4 (0.53) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| SCHEMBL9424741 | 0.81 | DRD3 (0.55) | CYP3A4CYP2C19CYP2C9DRD2DRD4 | |
| SCHEMBL8963668 | 0.80 | DRD2 (0.64) | CYP3A4CYP2C19CYP2C9DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514800-A | CALCIUM CHANNEL BLOCKERS, CEREBRAL ISCHEMIA | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1996-05-07 | — | — | US | disclosed |
| US-5276034-A | Cardiovascular disorders, nervous system disorders, diuretics, antiischemic agents or antispasmodic agents | SYNTEX PHARMACEUTICAL LTD. (GB) | 1994-01-04 | — | — | US | disclosed |
| US-5043447-A | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1991-08-27 | — | — | US | disclosed |