Lifarizine

Lifarizine

SCHEMBL94691

Cc1ccc(-c2nc(C)c(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)[nH]2)cc1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.57
CYP2C19 P33261 2/20 0.57
CYP2C9 P11712 1/20 0.57
NPSR1 Q6W5P4 3/20 0.46
LMNA P02545 3/20 0.46
HTT P42858 1/20 0.46
ALDH1A1 P00352 1/20 0.44
DRD2 P14416 2/20 0.44
DRD4 P21917 2/20 0.44
DRD3 P35462 2/20 0.44
USP2 O75604 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
HPN P05981 1/20 0.44
CHRM2 P08172 1/20 0.44
ADRA2A P08913 1/20 0.44
ADORA3 P0DMS8 1/20 0.44
CHRM1 P11229 1/20 0.44
ADRA2C P18825 1/20 0.44
CNR1 P21554 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lifarizine SCHEMBL14809613 1.00 CYP3A4 (0.57) CYP3A4CYP2C19CYP2C9NPSR1LMNA
Lifarizine SCHEMBL2231142 0.99 CYP3A4 (0.56) CYP3A4CYP2C19CYP2C9NPSR1LMNA
SCHEMBL9146587 0.94 LMNA (0.51) CYP3A4CYP2C19CYP2C9NPSR1LMNA
SCHEMBL8989078 0.88 CYP2D6 (0.48) CYP3A4CYP2C19CYP2C9NPSR1LMNA
Lifarizine SCHEMBL676318 0.84 DRD2 (0.57) CYP3A4CYP2C19CYP2C9NPSR1LMNA
SCHEMBL8963681 0.84 CYP3A4 (0.53) CYP3A4CYP2C19CYP2C9NPSR1LMNA
SCHEMBL8963806 0.83 CYP3A4 (0.56) CYP3A4CYP2C19CYP2C9NPSR1LMNA
Lifarizine SCHEMBL8963776 0.83 DRD2 (0.56) CYP3A4CYP2C19CYP2C9NPSR1LMNA
SCHEMBL8963453 0.83 CYP3A4 (0.52) CYP3A4CYP2C19CYP2C9NPSR1LMNA
SCHEMBL8963815 0.81 CYP3A4 (0.53) CYP3A4CYP2C19CYP2C9NPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1458 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK NEW YORK UNIVERSITY (US) 2026-02-12 US claimed
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. 2025-01-30 US claimed
EP-4297868-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE Hoth Therapeutics, Inc. (US) 2024-01-03 EP claimed
US-20230165812-A1 NOCICEPTOR NEURONS CONTROL CANCER IMMUNOSURVEILLANCE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-06-01 US claimed
WO-2022182658-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. (US) 2022-09-01 WO claimed
US-20220016046-A1 PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS CHILDREN'S MEDICAL CENTER CORPORATION (US) 2022-01-20 US claimed
US-20210290561-A1 PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS CHILDREN'S MEDICAL CENTER CORPORATION (US) 2021-09-23 US claimed
US-20210186906-A1 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2021-06-24 US claimed
CN-109893528-A Koumine treats the purposes of disorders of lipid metabolism and its related disease or illness 福建医科大学 2019-06-18 CN claimed
US-20170319517-A1 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS THE GENERAL HOSPITAL CORPORATION 2017-11-09 US claimed
US-20020040042-A1 Inhibition of noninactivating Na channels of mammalian optic nerve as a means of preventing optic nerve degeneration associated with glaucoma ALLERGAN, INC. 2002-04-04 US claimed
US-20020013353-A1 Inhibition of noninactivating Na channels of mammalian optic nerve as a means of preventing optic nerve degeneration associated with glaucoma ALLERGAN, INC. 2002-01-31 US claimed
US-6326389-B1 ADMINISTERING SODIUM CHANNEL MODULATORS ALLERGAN SALES, INC. 2001-12-04 US claimed
EP-1011656-A2 A METHOD FOR TREATING TENSION-TYPE HEADACHE Head Explorer ApS (DK) 2000-06-28 EP claimed
CN-1251520-A Use of sodium channel blocker in manfacture of medicament for preventing optic nerve degeneration associated with glaucoma ALLERGAN SALES INC (US) 2000-04-26 CN claimed
EP-0973500-A1 USE OF SODIUM CHANNEL BLOCKER IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTING OPTIC NERVE DEGENERATION ASSOCIATED WITH GLAUCOMA Allergan Sales, Inc. (US) 2000-01-26 EP claimed
US-5922746-A Inhibition of noninactivating Na channels of mammalian optic nerve as a means of preventing optic nerve degeneration associated with glaucoma ALLERGAN (US) 1999-07-13 US claimed
WO-1998043612-B1 USE OF SODIUM CHANNEL BLOCKER IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTING OPTIC NERVE DEGENERATION ASSOCIATED WITH GLAUCOMA 1998-11-12 WO claimed
WO-1998043612-A1 USE OF SODIUM CHANNEL BLOCKER IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTING OPTIC NERVE DEGENERATION ASSOCIATED WITH GLAUCOMA ALLERGAN SALES, INC. (US) 1998-10-08 WO claimed
WO-1998019674-A2 A METHOD FOR TREATING TENSION-TYPE HEADACHE HEAD EXPLORER APS (DK) 1998-05-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170319517-A1 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS TRPV1, TRPV2, TRPV3 CYP3A4 4526/4885CYP2C19 3786/4885CYP2C9 3257/4885
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE TACR1, ACHE, TACR2 CYP3A4 2316/4885CYP2C19 1886/4885CYP2C9 3070/4885
US-20230165812-A1 NOCICEPTOR NEURONS CONTROL CANCER IMMUNOSURVEILLANCE OPRL1, MRGPRX1, RAMP1 CYP3A4 4368/4885CYP2C19 4625/4885CYP2C9 4155/4885
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK EPB41L2, MYLK2, RABL3 CYP3A4 4337/4885CYP2C19 4330/4885CYP2C9 4573/4885
US-20210290561-A1 PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS TRPV1, CACNA1B, ORAI1 CYP3A4 4501/4885CYP2C19 4496/4885CYP2C9 3962/4885
US-20220016046-A1 PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS CACNA1B, TRPV1, ORAI1 CYP3A4 4504/4885CYP2C19 4487/4885CYP2C9 3958/4885
US-20210186906-A1 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS TRPV1, TRPV2, TRPV3 CYP3A4 4526/4885CYP2C19 3786/4885CYP2C9 3257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.