SCHEMBL8963474

SCHEMBL8963474

Cc1ccc(-c2nc(C(O)C(C)C)c(C(C)(C)C)[nH]2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPBWR1 P48145 1/20 0.35
TNKS O95271 3/20 0.35
PARP1 P09874 3/20 0.35
TNKS2 Q9H2K2 3/20 0.35
CHEK2 O96017 3/20 0.34
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
KMT2A Q03164 1/20 0.33
MAPT P10636 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
DCUN1D1 Q96GG9 1/20 0.33
MAPK13 O15264 1/20 0.32
GCGR P47871 1/20 0.32
MAPK12 P53778 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8963890 0.99 RAB9A (0.35) RAB9ASMN1; SMN2NPBWR1TNKSPARP1
Hydrochloric Acid SCHEMBL8963856 0.82 RAB9A (0.35) RAB9ASMN1; SMN2NPBWR1TNKSPARP1
Hydrochloric Acid SCHEMBL8963908 0.81 RAB9A (0.37) RAB9ASMN1; SMN2NPBWR1TNKSPARP1
SCHEMBL8963749 0.81 ALDH1A1 (0.44) RAB9ASMN1; SMN2NPBWR1TNKSPARP1
SCHEMBL8963655 0.77 HDAC6 (0.44) RAB9ASMN1; SMN2NPBWR1TNKSPARP1
Hydrochloric Acid SCHEMBL8963738 0.72 PRMT5 (0.37) TNKSPARP1TNKS2MEN1KMT2A
SCHEMBL8963493 0.71 MAPK1 (0.44) RAB9ASMN1; SMN2TNKSPARP1TNKS2
SCHEMBL8963883 0.71 IKBKB (0.47) RAB9ASMN1; SMN2NPBWR1TNKSPARP1
Hydrochloric Acid SCHEMBL10647849 0.70 RAB9A (0.33) RAB9ASMN1; SMN2NPBWR1TNKSPARP1
Hydrochloric Acid SCHEMBL8963485 0.70 CYP2C19 (0.41) SMN1; SMN2KDM4EMEN1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5514800-A CALCIUM CHANNEL BLOCKERS, CEREBRAL ISCHEMIA SYNTEX PHARMACEUTICALS, LTD. (GB) 1996-05-07 US disclosed
US-5276034-A Cardiovascular disorders, nervous system disorders, diuretics, antiischemic agents or antispasmodic agents SYNTEX PHARMACEUTICAL LTD. (GB) 1994-01-04 US disclosed
US-5252736-A Calcium channel antagonists SYNTEX PHARMACEUTICALS, LTD. (GB) 1993-10-12 US disclosed
EP-0289227-B1 SUBSTITUTED IMIDAZOLYL-ALKYL-PIPERAZINE AND -DIAZEPINE DERIVATIVES SYNTEX PHARMACEUTICALS LTD. (GB) 1992-04-08 EP disclosed
US-5091428-A Calcium channel blockers preferential for cerebral blood vessels SYNTEX PHARMACEUTICALS, LTD. (BM) 1992-02-25 US disclosed
US-5043447-A Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives SYNTEX PHARMACEUTICALS, LTD. (GB) 1991-08-27 US disclosed
US-5010075-A Antiepilepic, hypotensive, antiarrhythmia, antiischemic agent SYNTEX PHARMACEUTICALS LTD. (GB) 1991-04-23 US disclosed
US-4935417-A CALCIUM CHANNEL BLOCKERS SYNTEX PHARMACEUTICALS LTD. (BM) 1990-06-19 US disclosed
US-4829065-A Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives SYNTEX PHARMACEUTICALS, LTD. (GB) 1989-05-09 US disclosed
EP-0289227-A1 Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives SYNTEX PHARMACEUTICALS LTD. (GB) 1988-11-02 EP disclosed