Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963754 | 0.89 | MAPT (0.53) | MAPTDRD2DRD4DRD3GAA | |
| SCHEMBL8964060 | 0.85 | DRD2 (0.53) | MAPTDRD2DRD4DRD3GAA | |
| SCHEMBL8963551 | 0.85 | DRD2 (0.51) | MAPTDRD2DRD4DRD3GAA | |
| SCHEMBL9424936 | 0.83 | MAPT (0.53) | MAPTDRD2DRD4DRD3TSHR | |
| SCHEMBL8963541 | 0.81 | DRD2 (0.49) | MAPTDRD2DRD4DRD3GAA | |
| SCHEMBL8963668 | 0.79 | DRD2 (0.64) | MAPTDRD2DRD4DRD3GAA | |
| SCHEMBL8963948 | 0.79 | DRD3 (0.47) | MAPTDRD2DRD4DRD3GAA | |
| SCHEMBL8963520 | 0.78 | DRD2 (0.45) | MAPTDRD2DRD4DRD3GAA | |
| SCHEMBL8963729 | 0.77 | DRD2 (0.46) | MAPTDRD2DRD4DRD3LMNA | |
| SCHEMBL8969984 | 0.77 | LMNA (0.47) | MAPTDRD2DRD4DRD3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514800-A | CALCIUM CHANNEL BLOCKERS, CEREBRAL ISCHEMIA | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1996-05-07 | — | — | US | disclosed |