Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964346 | 0.77 | CA2 (0.52) | IDO1CA2CAMK2A | |
| SCHEMBL20618816 | 0.75 | IDO1 (0.44) | IDO1 | |
| SCHEMBL8964685 | 0.75 | IDO1 (0.44) | IDO1 | |
| SCHEMBL8858040 | 0.75 | MEN1 (0.41) | IDO1 | |
| SCHEMBL127369 | 0.74 | IDO1 (0.69) | IDO1FOLH1 | |
| SCHEMBL1333665 | 0.74 | CES1 (0.52) | IDO1 | |
| SCHEMBL8964691 | 0.73 | GABRA1 (0.38) | CA2 | |
| SCHEMBL15251712 | 0.72 | IDO1 (0.46) | IDO1FOLH1ANPEPENPEPCA2 | |
| SCHEMBL2357364 | 0.70 | CA2 (0.62) | IDO1FOLH1ANPEPENPEPCA2 | |
| SCHEMBL2048980 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410379-B1 | Pharmaceutically active 3-aryl and 3-heteroaryl-2-fluoro-1-olefins | MERRELL DOW PHARMA (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5068465-A | Hypotensive agents or enzyme inhibitors for treatment of hypertension | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0410379-A2 | Pharmaceutically active 3-aryl and 3-heteroaryl-2-fluoro-1-olefins | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4981868-A | ENZYME INHIBITORS, HYPOTENSIVES | MERRELL DOW PHARMACEUTICAL (US) | 1991-01-01 | — | — | US | disclosed |