Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490711 | 0.85 | CDC25B (0.49) | AKR1B1CDC25BMEN1KMT2ACYP1A2 | |
| SCHEMBL21822099 | 0.84 | L3MBTL1 (0.49) | CYP1A2L3MBTL1MTNR1BNQO1NQO2 | |
| SCHEMBL15345649 | 0.84 | MEN1 (0.48) | AKR1B1CDC25BMEN1KMT2ACYP1A2 | |
| SCHEMBL5252235 | 0.84 | MEN1 (0.48) | AKR1B1CDC25BMEN1KMT2ACYP1A2 | |
| SCHEMBL4699483 | 0.84 | MEN1 (0.48) | AKR1B1CDC25BMEN1KMT2ACYP1A2 | |
| SCHEMBL4702310 | 0.84 | MEN1 (0.48) | AKR1B1CDC25BMEN1KMT2ACYP1A2 | |
| SCHEMBL30747862 | 0.83 | GRM5 (0.37) | AKR1B1CDC25BMEN1KMT2ACYP1A2 | |
| SCHEMBL29151462 | 0.83 | GRM5 (0.37) | AKR1B1CDC25BMEN1KMT2ACYP1A2 | |
| SCHEMBL6856603 | 0.82 | MTNR1A (0.59) | CYP1A2CYP2A6TDP1L3MBTL1MTNR1A | |
| SCHEMBL20562784 | 0.81 | TAAR1 (0.51) | AKR1B1MEN1KMT2ACYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538970-A | Treatment of cancer with imidazo-1,2-pyridazin compounds | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5447956-A | Anticarcinogenic agents | BURROUGHS WELLCOME CO. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5371219-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1994-12-06 | — | — | US | disclosed |
| EP-0305093-B1 | Imidazo(1,2-b)pyridazine derivatives | WELLCOME FOUND (GB) | 1994-04-06 | — | — | EP | disclosed |
| US-5091531-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0305093-A1 | Imidazo(1,2-b)pyridazine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |