Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAD52 | P43351 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8965886 | 0.90 | PTPN1 (0.44) | MEN1KMT2ARAD52ESR1ESR2 | |
| SCHEMBL8970603 | 0.89 | ESR1 (0.42) | MEN1KMT2ARAD52ESR1ESR2 | |
| SCHEMBL17765400 | 0.83 | TP53 (0.44) | ESR1ESR2HTR2AMAOB | |
| SCHEMBL8966126 | 0.82 | ESR1 (0.66) | ESR1ESR2LTA4H | |
| SCHEMBL8965793 | 0.81 | ESR1 (0.68) | ESR1ESR2LTA4H | |
| SCHEMBL8966242 | 0.81 | ESR1 (0.68) | ESR1ESR2LTA4H | |
| SCHEMBL8966375 | 0.81 | ESR1 (0.46) | MEN1KMT2AESR1ESR2PTPN1 | |
| SCHEMBL7527079 | 0.81 | ESR1 (0.42) | ESR1ESR2KDM4EALDH1A1KDR | |
| SCHEMBL7528465 | 0.80 | ESR1 (0.52) | ESR1ESR2KDRFLT3 | |
| SCHEMBL8965875 | 0.80 | TP53 (0.37) | MEN1KMT2ARAD52ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |