Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7531367 | 0.83 | ESR1 (0.44) | ESR1ESR2KDM4EALDH1A1DPP4 | |
| SCHEMBL7530398 | 0.83 | ESR1 (0.64) | ESR1ESR2 | |
| SCHEMBL7528465 | 0.83 | ESR1 (0.52) | ESR1ESR2KDRFLT3 | |
| SCHEMBL7527453 | 0.83 | ESR1 (0.43) | ESR1ESR2KDRTDP1 | |
| SCHEMBL8965880 | 0.81 | MEN1 (0.46) | ESR1ESR2KDRFLT3MAOB | |
| SCHEMBL7528919 | 0.80 | ESR1 (0.41) | ESR1ESR2KDR | |
| SCHEMBL7138825 | 0.76 | ESR1 (0.39) | ESR1ESR2KDRMAOB | |
| SCHEMBL8609168 | 0.75 | ESR1 (0.68) | ESR1ESR2FLT3 | |
| SCHEMBL7535540 | 0.75 | ESR1 (0.47) | ESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL7526145 | 0.74 | ESR1 (0.59) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832881-B1 | Benzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0832881-A2 | Benzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |