Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8965880 | 0.90 | MEN1 (0.46) | PTPN1ESR1ESR2KMT2AMEN1 | |
| SCHEMBL8970603 | 0.87 | ESR1 (0.42) | PTPN1ESR1ESR2KMT2AMEN1 | |
| SCHEMBL7527453 | 0.84 | ESR1 (0.43) | ESR1ESR2KMT2AKDRALK | |
| SCHEMBL17765400 | 0.81 | TP53 (0.44) | ESR1ESR2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8966126 | 0.80 | ESR1 (0.66) | ESR1ESR2HTTLTA4H | |
| SCHEMBL8965794 | 0.80 | ESR1 (0.42) | ESR1ESR2KMT2AMEN1HTT | |
| SCHEMBL8965793 | 0.80 | ESR1 (0.68) | ESR1ESR2HTTLTA4H | |
| SCHEMBL8966242 | 0.80 | ESR1 (0.68) | ESR1ESR2HTTLTA4H | |
| SCHEMBL8966375 | 0.80 | ESR1 (0.46) | PTPN1ESR1ESR2KMT2AMEN1 | |
| SCHEMBL8966583 | 0.78 | THRA (0.43) | ESR1ESR2KDRALKMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |