Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373480 | 0.93 | PIK3CA (0.40) | PIK3CAKDRKDM4ERIPK1PIK3CD | |
| SCHEMBL8965977 | 0.88 | PIK3CA (0.44) | PIK3CAKDRKDM4ERIPK1PIK3CD | |
| SCHEMBL8965590 | 0.86 | PIK3CA (0.45) | PIK3CAKDRRIPK1PIK3CDPIK3CG | |
| SCHEMBL8965978 | 0.84 | PIK3CA (0.40) | PIK3CAKDRRIPK1PIK3CDPIK3CG | |
| SCHEMBL8965644 | 0.83 | PIK3CA (0.42) | PIK3CAKDRKDM4ERIPK1CSNK1D | |
| SCHEMBL9369315 | 0.80 | PIK3CA (0.46) | PIK3CAKDRKDM4ERIPK1PIK3CD | |
| SCHEMBL8965975 | 0.80 | PIK3CA (0.45) | PIK3CAKDRRIPK1PIK3CDPIK3CG | |
| SCHEMBL8965640 | 0.80 | KDR (0.44) | PIK3CAKDRKDM4EPIK3CDPIK3CG | |
| SCHEMBL8965525 | 0.80 | PIK3CA (0.41) | PIK3CAKDRKDM4ERIPK1PIK3CD | |
| SCHEMBL8965523 | 0.79 | PIK3CA (0.47) | PIK3CAKDRRIPK1PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538970-A | Treatment of cancer with imidazo-1,2-pyridazin compounds | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5447956-A | Anticarcinogenic agents | BURROUGHS WELLCOME CO. (US) | 1995-09-05 | — | — | US | disclosed |