Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966077 | 0.88 | MEN1 (0.43) | ESR1ESR2MEN1KMT2ANPC1 | |
| SCHEMBL8966375 | 0.84 | ESR1 (0.46) | ESR1ESR2MEN1KMT2ANPC1 | |
| SCHEMBL7527912 | 0.79 | ESR1 (0.46) | ESR1ESR2MEN1KMT2ANPC1 | |
| SCHEMBL7530844 | 0.77 | KMT2A (0.40) | ESR1ESR2MEN1KMT2ANPSR1 | |
| SCHEMBL7532969 | 0.76 | MEN1 (0.40) | ESR1ESR2MEN1KMT2ANPSR1 | |
| SCHEMBL8966236 | 0.75 | ESR1 (0.53) | ESR1ESR2MEN1KMT2ANPC1 | |
| SCHEMBL7528055 | 0.75 | MEN1 (0.40) | ESR1ESR2MEN1KMT2ANPSR1 | |
| SCHEMBL17765400 | 0.74 | TP53 (0.44) | ESR1ESR2NPSR1MYB | |
| SCHEMBL7528005 | 0.74 | MEN1 (0.42) | ESR1ESR2MEN1KMT2AALDH1A1 | |
| SCHEMBL8966091 | 0.74 | ESR1 (0.57) | ESR1ESR2NPC1RAB9AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |