Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966115 | 0.88 | ESR1 (0.39) | MEN1KMT2ARAB9ANPC1ESR1 | |
| SCHEMBL8966522 | 0.80 | SRD5A2 (0.43) | MEN1KMT2ARAB9ANPC1ESR1 | |
| SCHEMBL8966375 | 0.78 | ESR1 (0.46) | MEN1KMT2ANPC1ESR1ESR2 | |
| SCHEMBL8965846 | 0.77 | ESR1 (0.38) | MEN1KMT2ARAB9ANPC1ESR1 | |
| SCHEMBL9571847 | 0.77 | ESR1 (0.37) | MEN1KMT2ARAB9AESR1ESR2 | |
| SCHEMBL7530844 | 0.76 | KMT2A (0.40) | MEN1KMT2AESR1ESR2MAPT | |
| SCHEMBL8965809 | 0.75 | ESR1 (0.45) | MEN1KMT2ARAB9ANPC1ESR1 | |
| SCHEMBL7528055 | 0.73 | MEN1 (0.40) | MEN1KMT2AESR1ESR2MAPT | |
| SCHEMBL7528005 | 0.73 | MEN1 (0.42) | MEN1KMT2AESR1ESR2MAPT | |
| SCHEMBL7527912 | 0.72 | ESR1 (0.46) | MEN1KMT2ARAB9ANPC1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |