Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966734 | 0.93 | HRH3 (0.45) | HRH3MAPTALDH1A1TSHRHRH1 | |
| SCHEMBL7850426 | 0.83 | HRH3 (0.67) | HRH3MAPTSIGMAR1ALDH1A1TSHR | |
| SCHEMBL10778023 | 0.81 | HRH3 (0.65) | HRH3MAPTSIGMAR1ALDH1A1HRH1 | |
| SCHEMBL6246899 | 0.81 | HRH3 (0.65) | HRH3MAPTSIGMAR1ALDH1A1HRH1 | |
| SCHEMBL7866253 | 0.81 | HRH3 (0.65) | HRH3MAPTSIGMAR1ALDH1A1HRH1 | |
| SCHEMBL441058 | 0.79 | HRH3 (0.61) | HRH3MAPTSIGMAR1HRH1FPR3 | |
| SCHEMBL21016238 | 0.79 | HRH3 (0.61) | HRH3MAPTSIGMAR1HRH1FPR3 | |
| SCHEMBL38662815 | 0.79 | HRH3 (0.61) | HRH3MAPTSIGMAR1HRH1FPR3 | |
| Bromide SCHEMBL15941761 | 0.77 | HRH3 (0.58) | HRH3MAPTSIGMAR1HRH1FPR3 | |
| SCHEMBL439740 | 0.77 | HRH3 (0.56) | HRH3MAPTSIGMAR1ALDH1A1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468434-B1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL DOW PHARMA (US) | 1996-02-28 | — | — | EP | disclosed |
| US-5348964-A | Anticholesterol agents or fungicides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-20 | — | — | US | disclosed |
| EP-0468434-A1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |