Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22271407 | 0.92 | HRH3 (0.55) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL6678765 | 0.92 | HRH3 (0.62) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL8967208 | 0.87 | HRH3 (0.56) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL5665906 | 0.84 | HRH3 (0.93) | HRH3ALDH1A1MAPTCYP1A2MAPK1 | |
| Iodide SCHEMBL8913931 | 0.83 | HRH3 (0.52) | HRH3 | |
| SCHEMBL8966707 | 0.83 | HRH3 (0.52) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL4173915 | 0.81 | HRH3 (0.52) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL20761942 | 0.81 | HRH3 (0.61) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL9126300 | 0.81 | HRH3 (1.00) | HRH3ALDH1A1MAPTCYP1A2MAPK1 | |
| SCHEMBL3156252 | 0.81 | HRH3 (1.00) | HRH3ALDH1A1MAPTCYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114032-A1 | 4-AMINO SUBSTITUTED-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | Pfizer Products Inc. (US) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017165-A1 | 4-AMINO SUBSTITUTED-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-03-30 | — | — | WO | disclosed |