Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966707 | 0.93 | HRH3 (0.52) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL6678765 | 0.84 | HRH3 (0.62) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL172955 | 0.80 | HRH3 (0.56) | HRH3LSSMAPTCYP1A2MAPK1 | |
| SCHEMBL439729 | 0.80 | HRH3 (0.56) | HRH3LSSMAPTCYP1A2MAPK1 | |
| SCHEMBL22271407 | 0.80 | HRH3 (0.55) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL441058 | 0.78 | HRH3 (0.61) | HRH3LSSMAPTCYP1A2MAPK1 | |
| SCHEMBL439509 | 0.78 | HRH3 (0.52) | HRH3LSSMAPTCYP1A2MAPK1 | |
| SCHEMBL7850426 | 0.78 | HRH3 (0.67) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL7866253 | 0.76 | HRH3 (0.65) | HRH3ALDH1A1LSSMAPTCYP1A2 | |
| SCHEMBL20389744 | 0.76 | HRH3 (0.52) | HRH3ALDH1A1TSHRMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468434-B1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL DOW PHARMA (US) | 1996-02-28 | — | — | EP | disclosed |
| US-5348964-A | Anticholesterol agents or fungicides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-20 | — | — | US | disclosed |
| EP-0468434-A1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |