Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 6/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966212 | 0.89 | MET (0.45) | METMAPK10PSMB5PDGFRBPDGFRA | |
| SCHEMBL8966245 | 0.86 | AXL (0.47) | METMAPK10PSMB5PDGFRBPDGFRA | |
| SCHEMBL8966261 | 0.83 | PSMB5 (0.43) | METPSMB5PDGFRBPDGFRAHTT | |
| SCHEMBL1398196 | 0.81 | CYP1A2 (0.41) | HTTALDH1A1HPGDNPSR1PARP1 | |
| SCHEMBL9414452 | 0.80 | EGLN1 (0.40) | HTTALDH1A1MAPT | |
| SCHEMBL8503300 | 0.79 | KMT2A (0.45) | PDGFRBPDGFRAAXLMAP4K4CSNK1G2 | |
| SCHEMBL9411413 | 0.79 | PDE4B (0.43) | HTTALDH1A1HPGDNPSR1MAPT | |
| SCHEMBL8912395 | 0.77 | DHODH (0.49) | METMAPK10PSMB5AXLMAP4K4 | |
| SCHEMBL29213981 | 0.75 | MET (0.41) | METMAPK10PSMB5PDGFRBPDGFRA | |
| SCHEMBL8912894 | 0.75 | PARP1 (0.61) | METMAPK10PSMB5AXLMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694534-A1 | 3-Substituted quinoline-5-carboxylic acid derivatives and processes for their preparation | BAYER AG (DE) | 1996-01-31 | — | — | EP | disclosed |
| EP-0452712-B1 | 4-Quinolyl-dihydropyridines, process for their prepatation and their use in medicaments | BAYER AG (DE) | 1995-04-19 | — | — | EP | disclosed |
| EP-0476474-B1 | 4-Amino-3-hydroxy-phthalide and a method for its preparation | BAYER AG (DE) | 1994-12-28 | — | — | EP | disclosed |
| EP-0593930-A1 | 3-Substituted quinoline-5-carboxylic acids | BAYER AG (DE) | 1994-04-27 | — | — | EP | disclosed |
| EP-0476474-A1 | 4-Amino-3-hydroxy-phthalide and a method for its preparation | BAYER AG (DE) | 1992-03-25 | — | — | EP | disclosed |
| EP-0452712-A1 | 4-Quinolyl-dihydropyridines, process for their prepatation and their use in medicaments | BAYER AG (DE) | 1991-10-23 | — | — | EP | disclosed |