Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966245 | 0.86 | AXL (0.47) | PSMB5PDGFRBPDGFRAKDM4EHPGD | |
| SCHEMBL8967010 | 0.83 | MET (0.44) | PSMB5MAPTPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL8966212 | 0.81 | MET (0.45) | PSMB5MAPTPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL8911265 | 0.80 | ALDH1A1 (0.53) | NPC1RAB9AMAPTPOLBTP53 | |
| SCHEMBL8302290 | 0.76 | MEN1 (0.45) | RAB9AMAPTPOLBTP53ALDH1A1 | |
| SCHEMBL10440111 | 0.75 | TYMS (0.46) | RAB9AMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8502972 | 0.75 | PDGFRB (0.46) | NPC1RAB9AMAPTPDGFRBPDGFRA | |
| SCHEMBL9705890 | 0.74 | NR3C2 (0.40) | PSMB5NPC1RAB9AMAPTPOLB | |
| SCHEMBL9463382 | 0.74 | NR3C2 (0.51) | MAPTTP53ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8503300 | 0.72 | KMT2A (0.45) | RAB9AMAPTPDGFRBPDGFRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694534-A1 | 3-Substituted quinoline-5-carboxylic acid derivatives and processes for their preparation | BAYER AG (DE) | 1996-01-31 | — | — | EP | disclosed |
| EP-0452712-B1 | 4-Quinolyl-dihydropyridines, process for their prepatation and their use in medicaments | BAYER AG (DE) | 1995-04-19 | — | — | EP | disclosed |
| EP-0452712-A1 | 4-Quinolyl-dihydropyridines, process for their prepatation and their use in medicaments | BAYER AG (DE) | 1991-10-23 | — | — | EP | disclosed |