Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.72 |
| ▸ | BCR | P11274 | 4/20 | 0.72 |
| ▸ | PRKCA | P17252 | 4/20 | 0.72 |
| ▸ | SRC | P12931 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | PRKACA | P17612 | 2/20 | 0.60 |
| ▸ | PRKACG | P22612 | 2/20 | 0.60 |
| ▸ | PRKACB | P22694 | 2/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 6/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269 | 0.84 | ABL1 (1.00) | ABL1BCRPRKCASRCEGFR | |
| SCHEMBL8966527 | 0.82 | ABL1 (0.77) | ABL1BCRPRKCASRCEGFR | |
| SCHEMBL7468142 | 0.82 | PIK3CG (0.67) | SRCEGFRCSNK2A1SYKPIK3CG | |
| SCHEMBL8837915 | 0.81 | ABL1 (0.79) | ABL1BCRPRKCASRCEGFR | |
| SCHEMBL8837875 | 0.81 | ABL1 (0.78) | ABL1BCRPRKCASRCEGFR | |
| SCHEMBL1662 | 0.80 | ABL1 (0.77) | ABL1BCRPRKCASRCEGFR | |
| SCHEMBL8837795 | 0.80 | ABL1 (0.80) | ABL1BCRPRKCASRCEGFR | |
| SCHEMBL8837820 | 0.80 | PRKCA (1.00) | ABL1BCRPRKCASRCEGFR | |
| SCHEMBL8837778 | 0.80 | ABL1 (0.77) | ABL1BCRPRKCASRCEGFR | |
| SCHEMBL1255 | 0.80 | ABL1 (0.80) | ABL1BCRPRKCASRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672040-A1 | FURTHER PYRIMIDINE DERIVATIVES AND THEIR PREPARATION | Novartis AG (CH) | 1995-09-20 | — | — | EP | claimed |
| WO-1995009852-A1 | FURTHER PYRIMIDINE DERIVATIVES AND THEIR PREPARATION | CIBA-GEIGY AG (CH) | 1995-04-13 | — | — | WO | claimed |
| US-5543520-A | ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-08-06 | — | — | US | disclosed |