Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | SYK | P43405 | 4/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | CHUK | O15111 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466134 | 0.86 | MEN1 (0.62) | PIK3CGPIK3CAPIK3CBSYKSRC | |
| SCHEMBL7468136 | 0.84 | PIK3CG (0.68) | PIK3CGPIK3CAPIK3CBEGFRSYK | |
| SCHEMBL7470877 | 0.84 | CDK2 (0.70) | PIK3CGPIK3CAPIK3CBSYKSRC | |
| SCHEMBL13924462 | 0.83 | SYK (0.80) | PIK3CGPIK3CAPIK3CBEGFRSYK | |
| SCHEMBL8967100 | 0.82 | ABL1 (0.72) | PIK3CGPIK3CAPIK3CBEGFRSYK | |
| SCHEMBL12423165 | 0.82 | PIK3CG (0.68) | PIK3CGPIK3CAPIK3CBEGFRSYK | |
| SCHEMBL7464195 | 0.81 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBEGFRSYK | |
| SCHEMBL7460455 | 0.81 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CBEGFRSYK | |
| SCHEMBL27116598 | 0.81 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBEGFRSYK | |
| SCHEMBL2284467 | 0.81 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CBEGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |