SCHEMBL8967203

SCHEMBL8967203

O=C(c1ccc(Cl)cc1)c1ccc(Oc2ccc(O)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.77
HPGD P15428 2/20 0.61
PARP10 Q53GL7 1/20 0.58
ESR1 P03372 2/20 0.58
ESR2 Q92731 2/20 0.58
LMNA P02545 1/20 0.58
MAPT P10636 1/20 0.58
PKM P14618 1/20 0.58
HTT P42858 1/20 0.58
ELANE P08246 2/20 0.57
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
SRD5A2 P31213 3/20 0.53
FABP2 P12104 1/20 0.51
PPARG P37231 1/20 0.51
PPARA Q07869 1/20 0.51
SLC22A12 Q96S37 1/20 0.51
MMP1 P03956 1/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9507303 1.00 MAPK1 (0.77) MAPK1HPGDPARP10ESR1ESR2
SCHEMBL9506642 1.00 MAPK1 (0.77) MAPK1HPGDPARP10ESR1ESR2
SCHEMBL822861 0.92 HPGD (0.70) MAPK1HPGDPARP10LMNAMAPT
SCHEMBL12861795 0.92 HPGD (0.70) MAPK1HPGDPARP10LMNAMAPT
SCHEMBL822832 0.92 HPGD (0.70) MAPK1HPGDPARP10LMNAMAPT
SCHEMBL8071074 0.90 MAPT (0.71) MAPK1HPGDPARP10ESR1ESR2
SCHEMBL10486226 0.90 MAPT (0.71) MAPK1HPGDPARP10ESR1ESR2
SCHEMBL3471102 0.90 MAPT (0.71) MAPK1HPGDPARP10ESR1ESR2
SCHEMBL31012104 0.90 MAPT (0.71) MAPK1HPGDPARP10ESR1ESR2
SCHEMBL17209197 0.89 MAPK1 (0.61) MAPK1HPGDPARP10ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0306051-B1 Process for production of aromatic polyethers MITSUBISHI GAS CHEMICAL CO (JP) 1996-03-06 EP claimed
EP-0306051-B1 Process for production of aromatic polyethers MITSUBISHI GAS CHEMICAL CO (JP) 1996-03-06 EP disclosed
US-5395914-A Nucleophilic polycondensation of hydroxy halogen xanthones HOECHST AKTIENGESELLSCHAFT (DE) 1995-03-07 US disclosed
EP-0571883-A1 Polyarylethers with xanthone units, method for their production and their application HOECHST AKTIENGESELLSCHAFT (DE) 1993-12-01 EP disclosed
EP-0182648-B1 PROCESS FOR THE PREPARATION OF POLYETHERKETONES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-08-12 EP disclosed
US-5053477-A Reacting aromatic dihydroxy compound and aromatic dihalogeno compound containing a keto group in N-alkylcaprolactam solvent with mixture of alkali metal compounds including a carbonate BAYER AKTIENGESELLSCHAFT (DE) 1991-10-01 US disclosed
US-4999414-A Process for the production of aromatic polyether ketones BAYER AKTIENGESELLSCHAFT (DE) 1991-03-12 US disclosed
EP-0389902-A1 Process for producing aromatic polyetherketones BAYER AG (DE) 1990-10-03 EP disclosed
EP-0386542-A2 Process for preparation of aromatic polyetherketons BAYER AG (DE) 1990-09-12 EP disclosed
US-4954604-A High molecular weight, crystalline BAYER AKTIENGESELLSCHAFT (DE) 1990-09-04 US disclosed
US-4952665-A Process for production of aromatic polyethers with alkali metal carbonate/bicarbonate/fluoride cocatalyst MITSUBISHI GAS CHEMICAL COMPANY, LTD. (JP) 1990-08-28 US disclosed
EP-0354377-A2 Process for the preparation of aromatic polyether ketones BAYER AG (DE) 1990-02-14 EP disclosed
EP-0306051-A1 Process for production of aromatic polyethers MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1989-03-08 EP disclosed
US-4711945-A Polyketone IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-12-08 US disclosed
EP-0182648-A2 Process for the Preparation of Polyetherketones IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-05-28 EP disclosed
EP-0069598-B1 PREPARATION OF AROMATIC KETONES RAYCHEM CORPORATION (a California corporation) (US) 1984-12-19 EP disclosed
EP-0069598-A1 Preparation of aromatic ketones RAYCHEM CORPORATION (a California corporation) (US) 1983-01-12 EP disclosed