SCHEMBL8967239

SCHEMBL8967239

O=C(c1ccccc1)N(CCCSc1ccncc1)Cc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPAR1 Q92633 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
HDAC1 Q13547 4/20 0.45
HDAC6 Q9UBN7 4/20 0.45
RCE1 Q9Y256 1/20 0.43
HDAC3 O15379 2/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC2 Q92769 1/20 0.43
LTB4R2 Q9NPC1 1/20 0.43
TSHR P16473 1/20 0.42
SLC2A1 P11166 1/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8966681 0.99 LPAR1 (0.46) LPAR1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8966760 0.92 CYP1A2 (0.48) LPAR1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8966322 0.87 CYP2C9 (0.46) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL8967342 0.87 HDAC1 (0.44) CYP1A2CYP2C19HDAC1TSHRKMT2A
Hydrochloric Acid SCHEMBL8967045 0.86 CYP2C9 (0.44) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL8966843 0.86 L3MBTL1 (0.46) CYP1A2CYP2C19HDAC1TSHRKMT2A
SCHEMBL8967158 0.86 HDAC1 (0.49) HDAC1HDAC6TSHRKMT2AMEN1
SCHEMBL9252468 0.85 CYP1A2 (0.43) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL8966348 0.85 HDAC1 (0.48) HDAC1HDAC6TSHRKMT2AMEN1
SCHEMBL8966758 0.84 CYP2C19 (0.43) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5561147-A ANTIINFLAMMATORY AGENT, ANTIPYRETIC, ANALGESICS, ANTIALLERGENS, IMMUNOSUPPRESSANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-10-01 US disclosed
EP-0522606-B1 Pyridine derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1996-04-03 EP disclosed
US-5457106-A Antiinflammatory agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-10-10 US disclosed
US-5389658-A Administering as antipyretic, antiinflammatory, analgesic, antiallergic, or immunosupressive agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-02-14 US disclosed
EP-0612729-A2 Pyridine derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1994-08-31 EP disclosed
US-5246948-A Antiinflammatory, antipyretic, analgesic, antiallergic, immunosupressing or immunomodulating activity TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-09-21 US disclosed
EP-0522606-A2 Pyridine derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-01-13 EP disclosed