Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945769 | 0.91 | ESR1 (0.53) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL7946063 | 0.86 | ESR1 (0.49) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL7945783 | 0.86 | ESR2 (0.50) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL7942835 | 0.82 | ALDH1A1 (0.46) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL11187322 | 0.79 | ESR1 (0.55) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4660156 | 0.77 | ESR1 (0.79) | ALDH1A1KDM4EESR1ESR2 | |
| SCHEMBL7106199 | 0.77 | ESR1 (0.44) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL3976908 | 0.76 | ESR1 (0.55) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2824657 | 0.70 | CES1 (0.45) | KMT2AESR1ESR2SRD5A1CES1 | |
| SCHEMBL22146732 | 0.69 | SRD5A2 (0.50) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |
| US-4400543-A | ANTIFERTILITY AGENTS | ELI LILLY AND COMPANY (US) | 1983-08-23 | — | — | US | disclosed |