Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.49 |
| ▸ | WNT3A | P56704 | 2/20 | 0.49 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5258963 | 0.98 | MAPK1 (0.60) | MAPK1TYK2L3MBTL1CTNNB1WNT3A | |
| SCHEMBL1515738 | 0.84 | SMN1; SMN2 (0.60) | MAPK1L3MBTL1CTNNB1WNT3AERCC5 | |
| SCHEMBL30394799 | 0.84 | SMN1; SMN2 (0.60) | MAPK1L3MBTL1CTNNB1WNT3AERCC5 | |
| SCHEMBL11381286 | 0.81 | ERCC5 (0.51) | L3MBTL1CTNNB1WNT3AERCC5FEN1 | |
| SCHEMBL6276675 | 0.81 | NAPRT (0.56) | MAPK1CTNNB1WNT3AERCC5FEN1 | |
| Bromide SCHEMBL2691175 | 0.80 | ALDH1A1 (0.56) | MAPK1L3MBTL1SMN1; SMN2ALDH1A1GAA | |
| Bromide SCHEMBL8370980 | 0.80 | POLB (0.62) | L3MBTL1CTNNB1WNT3ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1156806 | 0.78 | JAK2 (0.53) | MAPK1TYK2ERCC5FEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8967880 | 0.78 | CYP19A1 (0.44) | MAPK1SMN1; SMN2ALDH1A1GAACYP19A1 | |
| Bromide SCHEMBL8968266 | 0.78 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1GAACYP19A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541032-A | CHARGE STABILIZERS WHICH ARE INSENSITIVE TO MOISTURE, HEAT RESISTANT AND PRODUCE CRISP, UNIFORM VISIBLE IMAGES OF HIGH COLOR INTENSITY | BASF AKTIENGESELLSCHAFT (DE) | 1996-07-30 | — | — | US | disclosed |