Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6281987 | 0.98 | POLB (0.63) | POLBSMN1; SMN2MAPTNPC1TSHR | |
| SCHEMBL29861033 | 0.85 | NPC1 (0.63) | POLBSMN1; SMN2NPC1RAB9ACTNNB1 | |
| SCHEMBL3282912 | 0.85 | NPC1 (0.63) | POLBSMN1; SMN2NPC1RAB9ACTNNB1 | |
| SCHEMBL19419913 | 0.83 | TP53 (0.56) | SMN1; SMN2MAPTNPC1RAB9ACTNNB1 | |
| Hydrochloric Acid SCHEMBL8968371 | 0.81 | IDO1 (0.61) | POLBNPC1TSHRRAB9AL3MBTL1 | |
| Bromide SCHEMBL8967719 | 0.80 | MAPK1 (0.59) | POLBSMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8968394 | 0.78 | NPC1 (0.50) | POLBSMN1; SMN2NPC1RAB9ACTNNB1 | |
| SCHEMBL5258963 | 0.78 | MAPK1 (0.60) | POLBSMN1; SMN2MAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11475020 | 0.77 | POLB (0.59) | POLBSMN1; SMN2MAPTNPC1TSHR | |
| Bromide SCHEMBL2691175 | 0.76 | ALDH1A1 (0.56) | SMN1; SMN2MAPTTSHRTP53USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004719-A | ACID-GENERATING LAYER OR PHASE COMPRISING A MIXTURE OF A SUPERACID PRECURSOR, A SENSITIZING DYE AND A SECONDARY ACID GENERATOR, AND A COLOR-CHANGE LAYER OR PHASE COMPRISING AN IMAGE DYE. | POLAROID CORPORATION (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0757629-B1 | IMAGING MEDIUM AND PROCESS | POLAROID CORP (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5631118-A | MULTILAYER ELEMENT WITH ACID GENERATING LAYER, ACID PRECURSOR, SENSITIZING DYE, ACID GENERATOR AND COLOR CHANGING LAYER | POLAROID CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0757629-A1 | IMAGING MEDIUM AND PROCESS | POLAROID CORPORATION (US) | 1997-02-12 | — | — | EP | disclosed |
| US-5541032-A | CHARGE STABILIZERS WHICH ARE INSENSITIVE TO MOISTURE, HEAT RESISTANT AND PRODUCE CRISP, UNIFORM VISIBLE IMAGES OF HIGH COLOR INTENSITY | BASF AKTIENGESELLSCHAFT (DE) | 1996-07-30 | — | — | US | disclosed |
| WO-1995029068-A1 | IMAGING MEDIUM AND PROCESS | POLAROID CORPORATION (US) | 1995-11-02 | — | — | WO | disclosed |
| US-5441850-A | Exposing medium to actinic radiation in specified wavelength so sensitizing dye decomposes superacid precursor, heating to decompose secondary acid generator, mixing acid generating and color change layers to form image, providing base to restore | POLAROID CORPORATION (US) | 1995-08-15 | — | — | US | disclosed |