Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 5/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11537315 | 0.82 | PABPC1 (0.64) | PABPC1IDO1HTTEP300KAT8 | |
| SCHEMBL227125 | 0.77 | TSHR (0.61) | HTTTSHR | |
| SCHEMBL30612357 | 0.77 | TSHR (0.61) | HTTTSHR | |
| SCHEMBL8852163 | 0.77 | CDC25B (0.54) | CDC25BIMPDH2IMPDH1IDO1PLK1 | |
| SCHEMBL29380721 | 0.76 | IDO1 (0.73) | CDC25BIMPDH2IMPDH1IDO1PLK1 | |
| SCHEMBL419307 | 0.76 | IDO1 (0.73) | CDC25BIMPDH2IMPDH1IDO1PLK1 | |
| SCHEMBL3567490 | 0.74 | HTT (0.42) | HTTMEN1KMT2ATSHR | |
| SCHEMBL29506423 | 0.74 | PABPC1 (0.59) | CDC25BPABPC1MEN1KMT2AKEAP1 | |
| SCHEMBL15453221 | 0.74 | PABPC1 (0.59) | CDC25BPABPC1MEN1KMT2AKEAP1 | |
| SCHEMBL24101640 | 0.74 | EP300 (0.60) | CDC25BHTTEP300KAT8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |