Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ADH1B | P00325 | 1/20 | 0.43 |
| ▸ | ADH1C | P00326 | 1/20 | 0.43 |
| ▸ | ADH1A | P07327 | 1/20 | 0.43 |
| ▸ | ADH4 | P08319 | 1/20 | 0.43 |
| ▸ | ADH7 | P40394 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octane SCHEMBL23406315 | 0.85 | TDP1 (0.62) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| Propylene Glycol SCHEMBL28029073 | 0.85 | TDP1 (0.62) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| Dodecane SCHEMBL1656240 | 0.85 | TDP1 (0.62) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| Heptane SCHEMBL9721452 | 0.85 | TDP1 (0.62) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| Tetradecane SCHEMBL28128676 | 0.85 | TDP1 (0.62) | ALDH1A1TSHRTDP1LMNAKDM4E | |
| SCHEMBL15378599 | 0.84 | ALDH1A1 (0.56) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL1270840 | 0.84 | ALDH1A1 (0.56) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL8398870 | 0.84 | ALDH1A1 (0.56) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| Alcohol SCHEMBL29133523 | 0.83 | ALDH1A1 (0.77) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| Alcohol SCHEMBL28919456 | 0.83 | ALDH1A1 (0.77) | ALDH1A1TSHRS1PR2S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509149-B1 | Thermal dye sublimation transfer receiving element | AGFA GEVAERT NV (BE) | 1996-03-13 | — | — | EP | disclosed |
| US-5376618-A | Receiver layer contains copolyester from diols, dicarboxylic acids and long chain alkyl hydroxy-carboxylic acids | AGFA-GEVAERT, N.V. (BE) | 1994-12-27 | — | — | US | disclosed |
| EP-0481130-B1 | Thermal dye sublimation transfer receiving element | AGFA GEVAERT NV (BE) | 1994-06-08 | — | — | EP | disclosed |
| EP-0481129-B1 | Thermal dye sublimation transfer receiving element | AGFA GEVAERT NV (BE) | 1994-05-18 | — | — | EP | disclosed |
| US-5284815-A | Image-receiving layer containing an isocyanate-based polymer having a crosslinked and cured surface; dyeability; releasability from the dye donor element | AGFA-GEVAERT, N.V. (BE) | 1994-02-08 | — | — | US | disclosed |
| EP-0509149-A1 | Thermal dye sublimation transfer receiving element | AGFA-GEVAERT N.V. (BE) | 1992-10-21 | — | — | EP | disclosed |
| EP-0481130-A1 | Thermal dye sublimation transfer receiving element | AGFA-GEVAERT N.V. (BE) | 1992-04-22 | — | — | EP | disclosed |