Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968177 | 0.81 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL23343643 | 0.80 | NAMPT (0.79) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL30051982 | 0.73 | MEN1 (0.77) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL9637653 | 0.73 | MEN1 (0.77) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL7482592 | 0.72 | KDM4E (0.52) | NPC1RAB9AMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL29388210 | 0.72 | MEN1 (0.74) | NPC1RAB9AMEN1KMT2AMAPT | |
| Bromide SCHEMBL29417998 | 0.72 | MEN1 (0.74) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL16881794 | 0.70 | NPC1 (0.75) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL8968218 | 0.70 | CYP11B1 (0.54) | NPC1RAB9AGRIK1MEN1KMT2A | |
| SCHEMBL12156880 | 0.70 | RAB9A (0.62) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |